Mefenamic Acid can cause side effects such as gastrointestinal issues, including nausea, diarrhea, and abdominal pain, and may increase the risk of serious conditions like ulcers, bleeding, or perforation in the digestive tract. It may also elevate the risk of heart attack or stroke, particularly in people with cardiovascular disease. Other potential side effects include kidney problems and allergic reactions like rash or swelling. Given these risks, it should be used with caution, especially in patients with heart or gastrointestinal concerns

 Mefenamic Acid carries significant warnings. It can increase the risk of heart attack and stroke, especially with prolonged use or in patients with cardiovascular disease. It also poses a risk of gastrointestinal bleeding, ulceration, and perforation, which can be fatal, particularly in those with a history of GI issues. Kidney damage may occur with long-term use, and the drug should be avoided in those with severe kidney impairment. It is contraindicated in patients who have had recent heart surgery (CABG) or have a history of severe allergic reactions to NSAIDs

An overdose of (Mefenamic Acid) can cause gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. It may also lead to kidney damage or more severe effects, including gastrointestinal bleeding and ulcers. In case of overdose, seek immediate medical attention. Treatment may involve supportive care to manage symptoms and prevent complications, such as kidney failure or bleeding​