Motrin (Ibuprofen) may cause side effects, ranging from mild to serious. Common side effects include nausea, stomach upset, headache, and dizziness. Some people may experience gastrointestinal issues such as heartburn, indigestion, or stomach pain. 

Motrin (Ibuprofen) carries several important warnings. Long-term use or overuse of ibuprofen increases the risk of gastric ulcers, bleeding, and perforation of the digestive tract, which can be fatal​. It can also elevate the risk of heart attack, stroke, and kidney damage, particularly when taken in high doses or for extended periods. People with pre-existing cardiovascular conditions, high blood pressure, or kidney issues should use ibuprofen with caution and under medical supervision

In the event of a Motrin (Ibuprofen) overdose, symptoms can range from mild to severe. Common signs of overdose include nausea, vomiting, stomach pain, drowsiness, and dizziness. More serious symptoms may include black or bloody stools, coughing up blood, shallow breathing, fainting, and even coma. 

If an overdose is suspected, it is crucial to seek immediate medical attention. The treatment may involve stomach pumping, administration of activated charcoal, and other interventions to manage symptoms and prevent further damage, particularly to the gastrointestinal tract, liver, and kidneys​.