Common side effects include headache, diarrhea, nausea, vomiting, and abdominal pain. Long-term use of pantoprazole can increase the risk of bone fractures, vitamin B12 deficiency, and magnesium deficiency.

Pantoprazole should be used with caution in individuals with liver disease or those who have a history of bone fractures. Prolonged use may increase the risk of certain infections like Clostridium difficile or pneumonia. It is important to follow the prescribed dose and duration to avoid complications, and regular monitoring may be necessary, particularly during long-term therapy. Pantoprazole can interact with other medications, including those that require stomach acid for proper absorption, such as certain antifungals and HIV medications.

Can lead to symptoms such as confusion, dizziness, severe diarrhea, abdominal pain, nausea, vomiting, headache, blurred vision, and a rapid heart rate. In some cases, individuals may experience severe fatigue or weakness. While pantoprazole is generally considered to have a low risk of toxicity, it is important to seek immediate medical attention if an overdose is suspected. Treatment typically involves supportive care, such as intravenous fluids to maintain hydration, monitoring vital signs, and managing any arising complications. There is no specific antidote for pantoprazole, but activated charcoal may be used in certain cases if the overdose occurred recently. Prompt medical intervention is crucial to prevent further complications.