Is primarily used to manage asthma and allergic rhinitis. As a leukotriene receptor antagonist, it works by blocking leukotrienes, which are chemicals in the body that cause inflammation and constriction of the airways. For asthma, zafirlukast is used for long-term treatment and prevention of symptoms, helping to reduce inflammation and prevent asthma attacks. It is also effective in managing allergic rhinitis, alleviating symptoms like sneezing, runny nose, and nasal congestion, which are triggered by allergens. Additionally, zafirlukast can be used to prevent exercise-induced bronchoconstriction (EIB), a condition where physical activity leads to asthma-like symptoms, by reducing the narrowing of the airways during exercise.
Common side effects of Zafirlukast include headache, dizziness, stomach upset, and diarrhea. More serious side effects may include liver problems, mood changes, or allergic reactions such as rash, swelling, or difficulty breathing.
Zafirlukast should be used with caution in individuals with liver disease since it can affect liver function. It may also interact with other medications, such as warfarin or theophylline, so it’s important to inform healthcare providers about any other medications being taken. In rare cases, it has been associated with neuropsychiatric events like agitation, depression, and suicidal thoughts, so patients should be monitored for any changes in mood or behavior. Zafirlukast is not intended for the treatment of acute asthma attacks and should be used as part of a long-term asthma management plan.
Can lead to dizziness, severe headache, stomach pain, nausea, vomiting, and fatigue. While the risk of acute toxicity is generally low, an overdose should still be treated as a medical emergency. In case of overdose, it is important to seek immediate medical attention. Treatment usually involves supportive care, such as symptom management and monitoring, as there is no specific antidote for zafirlukast. In some cases, activated charcoal may be used if the overdose occurred recently, and more severe cases may require additional medical intervention to prevent complications. It is crucial to adhere to the prescribed dosage to avoid the risk of overdose.